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The topical corticosteroids constitute a psoriazis Lipetsk of primarily synthetic steroids used as anti-inflammatory and anti-pruritic agents. Hydrocortisone is included in this class of synthetic corticosteroid. Chemically, hydrocortisone is pregnene-3,dione,11,17,trihydroxy- 11β - its molecular formula is C 21 H 30 O 5 ; its molecular weight is The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear.
There is some evidence to suggest that a recognizable psoriazis Lipetsk exists between vasoconstrictor potency and therapeutic efficacy in man. The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.
Topical corticosteroids can be absorbed from normal intact skin. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic psoriazis Lipetsk similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys.
Some of the topical corticosteroids and their psoriazis Lipetsk are also excreted into the bile. Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity psoriazis Lipetsk any of the components of the preparation.
Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings.
Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests.
If HPA axis suppression is noted, an psoriazis Lipetsk should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid. Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug.
Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids. If irritation develops, topical corticosteroids should be discontinued and appropriate therapy psoriazis Lipetsk. In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted.
If psoriazis Lipetsk favorable response does tratamentul psoriazisului anticorpi în occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.
Patients using topical corticosteroids should receive the following information and instructions. Long-term animal studies have not been performed to evaluate the carcinogenic potential or the effect on fertility of topical corticosteroids. Studies to psoriazis Lipetsk mutagenicity with prednisolone and hydrocortisone have revealed negative results. Corticosteroids are generally teratogenic in laboratory animals psoriazis Lipetsk administered systemically in relatively low dosage psoriazis Lipetsk. The http://pnkslm.net/psoriazis-cura.php potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals.
There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not 1 cr balsamurilor împotriva psoriazisului cumpăra used extensively on pregnant patients, in large amounts, or for prolonged this web page of time.
It is not known whether topical administration of corticosteroids could result in sufficient psoriazis Lipetsk absorption to produce detectable quantities in breast milk. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant.
Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman. Manifestations of adrenal suppression in children read article linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation.
Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema. Administration of topical corticosteroids to children should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with psoriazis Lipetsk growth and development of children. The psoriazis Lipetsk local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings.
These reactions are listed in an approximate decreasing order of occurrence: Topical corticosteroids are generally applied to the affected area as a thin film from two read article four times daily depending psoriazis Lipetsk the severity of the condition.
If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted. Anal Itching, Aphthous Stomatitis, Recurrent, Atopic Dermatitis, Dermatitis, Eczema, Click, Hemorrhoids, Intertrigo, Psoriasis vulgaris Plaque PsoriasisPsoriasis, Pruritus, Proctitis, Seborrheic Dermatitis, Skin Rash, Ulcerative Colitis, Ulcerative Colitis, Active Class: Psoriazis Lipetsk, gel, liniment or balm, lotion, ointment, etc Ingredients: Hydrocortisone, Stearyl Alcohol, Glyceryl here Polyoxyl 40 Stearate, Isopropyl Palmitate, Paraffin, Sorbitan Monostearate, Glycerin, Lactic Acid, Potassium Sorbate, Purified Water.
Anal Itching, Aphthous Stomatitis, Recurrent, Atopic Dermatitis, Dermatitis, Eczema, Gingivitis, Hemorrhoids, Intertrigo, Psoriasis vulgaris Plaque PsoriasisPsoriasis, Pruritus, Proctitis, Seborrheic Dermatitis, Skin Rash, Ulcerative Colitis, Ulcerative Colitis, Active.